Many clients at Velvet Skin & Laser come to us seeking a treatment that can improve skin quality, hydration and firmness without adding volume or changing facial shape. Nucleofill is a regenerative injectable made from high-purity polynucleotides — natural DNA fragments derived from salmon or trout cells. It works by stimulating your skin’s own repair processes at a cellular level.
This is not a filler or toxin. It is biocompatible, safe and non-toxic, designed for clients who want subtle, progressive improvement in dull, dehydrated or ageing skin.
In this guide we’ll cover:
- The common skin concerns Nucleofill addresses
- How the treatment works
- Realistic before & after results
- Cost and sessions
- Typical treatment areas
- Aftercare and side effects
- FAQs from our clients
The Problem: Dull, Dehydrated or Ageing Skin
Over time, skin loses hyaluronic acid, collagen and elastin due to ageing, sun exposure and lifestyle factors. This leads to dullness, fine lines, loss of firmness and a tired appearance. Many clients feel their skin looks dehydrated or lacks vitality, even with good skincare routines.
Nucleofill targets these issues by delivering polynucleotides that stimulate fibroblasts to produce more collagen and elastin, deeply hydrate the skin and provide antioxidant protection. It improves tone, texture and elasticity without adding volume or altering facial expression.
From our clinic experience, it is particularly helpful for clients in their 30s to 50s who want natural, gradual rejuvenation.
How Nucleofill Treatment Works
Nucleofill uses highly purified polynucleotides — natural DNA fragments from salmon or trout cells. These molecules are biocompatible and help stimulate the skin’s natural repair processes.
Procedure
- Consultation: We assess your skin and goals.
- Treatment: The polynucleotide solution is injected or delivered into the skin (30 minutes to 1 hour).
- Sessions: 3–4 sessions are typical.
The treatment works at a cellular level by stimulating fibroblasts, binding water molecules for hydration and improving microcirculation and oxygenation.
Realistic Nucleofill Before & After Results
Results develop gradually as your skin responds to the polynucleotides.
Common improvements
- Deep hydration and improved skin tone
- Enhanced texture and elasticity
- Firmer, brighter and healthier-looking skin
- Reduced fine lines and signs of ageing
Timeline
- Immediately after: Mild redness or swelling may occur (resolves 24–48 hours).
- 2–3 weeks: Visible improvements in hydration and glow.
- Result duration: Up to 6 weeks.
We recommend 3–4 sessions for optimal results. Results vary by individual factors like age and skin condition.
Cost & Sessions for Nucleofill
Session details
- Treatment time: 30 minutes to 1 hour
- Frequency: 3–4 sessions
- Back to work: Immediately
Pricing at Velvet Skin & Laser
- Nucleofill – Face: £295.00 (discounted to £190.00)
Treatment Areas for Nucleofill
Nucleofill is versatile and can be used on:
- Face: For overall rejuvenation, glow and firmness
- Neck: To improve crepey texture and laxity
- Décolletage: To smooth chest wrinkles
- Under-eye area: Using Nucleofill Eyes (specially formulated for delicate skin to reduce dark circles and puffiness)
- Hands: To restore volume and smoothness
It is suitable for most skin types and ideal for clients seeking natural, gradual improvement.
Recovery & Aftercare – What to Expect
Recovery
- No downtime — most clients return to normal activities straight away.
- Mild effects like redness, swelling or small injection marks may occur but are temporary.
Aftercare tips
- Avoid touching the treated area for 6 hours
- No makeup for 24 hours
- Avoid intense heat, exercise or alcohol for 48 hours
- Stay well-hydrated and follow skincare guidance
The treatment uses purified polynucleotides in a clinical setting.
Frequently Asked Questions
How long do Nucleofill results last?
Up to 6 weeks, with regular sessions recommended to maintain benefits.
Does Nucleofill hurt?
Most clients find it comfortable. Mild redness or swelling may occur but is temporary.
How many sessions do I need?
3–4 sessions for optimal results.
Can Nucleofill change my facial shape?
No — it works by signalling your skin to repair and regenerate, without adding volume.
Is Nucleofill safe?
Yes — it is biocompatible, safe and non-toxic. Mild side effects like redness or swelling may occur but are temporary.
How much does Nucleofill cost at Velvet Skin & Laser?
Face from £190.00 (discounted). Exact quote after assessment.
Ready to Rejuvenate Your Skin with Nucleofill?
Nucleofill treatment can improve hydration, firmness and glow — but it is most effective when tailored to your skin needs.
The first step is a consultation to assess your concerns and create a plan.
